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    Bunina bodies (seeFigure 2.24) are thought to be a specific feature of ALSand are small intracellular eosinophilic inclusions, oftenarranged in small beaded chains. In this early stage of development, synovial joints are beingformed between developing tarsal bones

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    In active patients able to trigger a breath,the ventilator switch to pressure support in?ation,automatically adjusting Pinsp to achieve the targetVT, and it delivers additional pressure-controlledin?ation if the patient’s RR is below the targetRR. Cardinal clinical manifestationsinclude fever, localized back pain and tenderness, radicu-lar pain, and myelopathy symptoms and signs, includingLhermitte phenomenon (paresthesia often described asan electric shock going down the back and limbs follow-ing neck flexion).

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    or CNS is the causative agent, the infection route is exog-enous with only a few exceptions.

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