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In fact, many of thedrugs, such as procainamide, phenytoin, bretylium, encainide,moricizine, tocainide, quinidine, etc.
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As far as cAMP regulation isconcerned, phosphodiesterases (PDEs) that were mentioned previously are enzymes thathydrolyze cAMP into 5‘ –AMP (Gancedo 2013).
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