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Chronic osteomyelitis: open excision andgrafting after saucerization. Twoimportant p53 regulators, MDM2 and MDMX, inactivate p53 by directly inhibit-ing its transcriptional activity and mediating its ubiquitination in a feedbackfashion, as their genes are also the transcriptional targets of p53. Recently, mogamulizumab, humanized monoclonal antibody against CCchemokine receptor 4 (CCR4) that is expressed in ATL cells, has been reported to showpotential efficacy for ATL . Michaelshook me and I know he was saying, “Julia, Julia, Julia, wake up!” And Iwas in the throes of some kind of dream Michaelshook me and I know he was saying, “Julia, Julia, Julia, wake up!” And Iwas in the throes of some kind of dream.
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